Automated Synthesis and Initial Evaluation of (4′-Amino-5′,8′-difluoro-1′H-spiro[piperidine-4,2′-quinazolin]-1-yl)(4-[18F]fluorophenyl)methanone for PET/MR Imaging of Inducible Nitric Oxide Synthase

Automated Synthesis and Initial Evaluation of (4′-Amino-5′,8′-difluoro-1′H-spiro[piperidine-4,2′-quinazolin]-1-yl)(4-[18F]fluorophenyl)methanone for PET/MR Imaging of Inducible Nitric Oxide Synthase

Background. Inducible nitric oxide synthase (iNOS) plays a crucial role in neuroinflammation, especially microglial activity, and may potentially represent a useful biomarker of neuroinflammation. In this study, we carefully defined a strategic plan to develop iNOS-targeted molecular PET imaging usi...

Full description

Saved in:

Bibliographic Details
Main Authors:	Skye Hsin-Hsien Yeh, Wen-Sheng Huang, Chuang-Hsin Chiu, Chuan-Lin Chen, Hui-Ting Chen, Dae Yoon Chi, Zhengxing Ge, Tsung-Hsun Yu, Pao-Yeh Wang, Yu-Yeh Kuo, Chun-Tse Hung, Geng-Ying Li, Chi-Wei Chang
Format:	Article
Language:	English
Published:	SAGE Publishing 2021-01-01
Series:	Molecular Imaging
Online Access:	http://dx.doi.org/10.1155/2021/9996125
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

[(2-Chlorophenyl)-(4-fluorophenyl)methylene]-(4-fluorophenyl)amine
by: Salvador Vilchis-Valdés, et al.
Published: (2024-09-01)

In Silico Identification and Characterization of Spiro[1,2,4]triazolo[1,5-<i>c</i>]quinazolines as Diacylglycerol Kinase α Modulators
by: Lyudmyla Antypenko, et al.
Published: (2025-05-01)

High-Yield Synthesis of <i>N</i><sup>4</sup>-(3-Chloro-4-fluorophenyl)-7-((4-methoxybenzyl)thio)quinazoline-4,6-diamine via <i>N</i>-(3-Chloro-4-fluorophenyl)-7-((4-methoxybenzyl)thio)-6-nitroquinazolin-4-amine
by: Susila Thapa, et al.
Published: (2025-01-01)

Methyl 6,7-Difluoro-2-[(4-fluorobenzyl)sulfanyl]-4-hydroxyquinoline-3-carboxylate
by: Vladimir A. Potapov, et al.
Published: (2024-09-01)

Diuretic activity of some 4- and 3-thio-substituted 1,2,4-triazoles with fluorophenyl fragments
by: O. A. Bihdan, et al.
Published: (2023-07-01)

Crystal structure of (4-(4-isopropylphenyl)-1H-pyrrol-3-yl)(ferrocenyl)methanone, C24H23FeNO
by: Tian Hangzhou, et al.
Published: (2025-06-01)

3-(4-Fluorophenyl)imidazo[1,2-a]pyridine-2-carbaldehyde
by: Firudin I. Guseinov, et al.
Published: (2025-06-01)

Anticonvulsant activity 2-((5-(3-(4-fluorophenyl)-4-R2-1,2,4-triazole-3-yl)-thio)-1-arylethanone
by: O. A. Bihdan
Published: (2019-12-01)

3'-R-Spiro[cycloalkyl-1(2), (hetaryl-3(4), 6'-[1,2,4]triazino[2,3-c]quinazoline]-2'(7'H)-2-оnes as a perspective class of compounds with actoprotective activity
by: O. S. Kolomoets, et al.
Published: (2017-04-01)

4,6-Diaryl-5,5-difluoro-1,3-dioxanes as chiral dopants for liquid crystal compositions
by: Maurice Médebielle, et al.
Published: (2024-11-01)

Prediction of biological activity of 4-(3,4 dimethoxybenzylidene)amino)-5-(2-fluorophenyl)-4H-1,2,4 triazole-3-thiol
by: V. P. Martynyshyn, et al.
Published: (2024-12-01)

Acute toxicity of 3-(2-, 3-fluorophenyl)-6-(aryl-, hetaryl)-[1,2,4]triazole[3,4-b][1,3,4]thiadiazoles
by: O. A. Bihdan, et al.
Published: (2017-12-01)

Physical-chemical properties of 5-(3-fluorophenyl)-4-amino-1,2,4-triazole-3-thiol s-derivatives
by: O. A. Bihdan, et al.
Published: (2017-08-01)

Crystal structure and Hirshfeld surface analysis of (2,7-diethoxynaphthalene-1,8-diyl)bis[(4-bromophenyl)methanone]
by: Kun Li, et al.
Published: (2024-12-01)

Crystal structure of 1-cyclopropyl-7-ethoxy-6,8-difluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid, C15H13F2NO4
by: Zhang Chun-Yan, et al.
Published: (2021-09-01)

Physical-chemical properties of 2-((5-(3-,4-fluorophenyl)-4-R2-1,2,4-triazol-3-il)tio)-1-arylethanons and their reduced systems
by: O. A. Bihdan
Published: (2019-07-01)

Photochemical Rearrangement of 8- methyl Spiro [2.5] oct-7-en-4-one to 4-methyl Spiro [2.5] oct-4-en-6-one
Published: (1989-12-01)

Study of the acute toxicity of 4-(3,4-dimethoxybenzylidene)amino)-5-(2-fluorophenyl)-4H-1,2,4-triazole-3-thiol by in silico and in vivo methods
by: V. P. Martynyshyn, et al.
Published: (2024-05-01)

Assessment of Acute Toxicity of Quinazoline Derivative 3-[2-oxo-2-(4-Phenylpiperazine-1-yl)Ethyl]quinazoline-4(3h)-oh Active against Opportunistic Microorganisms
by: N. M. Gabitova, et al.
Published: (2023-07-01)

A Systematic Review of Synthetic and Anticancer and Antimicrobial Activity of Quinazoline/Quinazolin‐4‐one Analogues
by: Neha Manhas, et al.
Published: (2025-07-01)

The study of UV-spectra of the sodium (3-oxo-3,4-dihydro-2H-[1,2,4]triazino[4,3-c]quinazolin-4-yl)acetate
by: О. V. Kryvoshey
Published: (2016-04-01)

Synthesis of Substituted 3,4-Dialkyl-2,6-Diaryl-Piperidin-4-ol Derivatives and Their Conformational Study
by: T. Maruthavanan, et al.
Published: (2012-01-01)

4-(8-Propyl-2,4-dithioxo-1,3-diazaspiro[4.5]decan-3-yl)spiro[1,5-dihydro-1,5-benzodiazepine-2,3′-indoline]-2′-one)
by: Dimitar Stoitsov, et al.
Published: (2025-05-01)

Effect of the Substitution of the Mesityl Group with Other Bulky Substituents on the Luminescence Performance of [Pt(1,3-bis(4-Mesityl-pyridin-2-yl)-4,6-difluoro-benzene)Cl]
by: Giulia De Soricellis, et al.
Published: (2025-03-01)

Synthesis and properties of S-alkyl 4-amino-5-(5-(3-fluorophenyl)-pyrazol-3-yl)-1,2,4-triazole-3-thiol derivatives
by: S. O. Fedotov, et al.
Published: (2023-04-01)

Crystal structure and Hirshfeld surface analysis of N-(4-nitrophenyl)-2-(piperidin-1-yl)acetamide (lidocaine analogue)
by: Imane Maimoune, et al.
Published: (2025-01-01)

Crystal structure and Hirshfeld surface analysis of 5,5-difluoro-10-[5-(trimethylsilyl)furan-2-yl]-5H-4λ4,5λ4-dipyrrolo[1,2-c:2′,1′-f][1,3,2]diazaborinine
by: Dmitriy M. Shchevnikov, et al.
Published: (2025-07-01)

STUDIES ON SPIROHETEROCYCLES : SYNTHESIS OF NEW SPIRO 4- THIAZOLIDINONES AS POSSIBLE BIODYNAMICS
Published: (1992-06-01)

Molecular and crystal structure of 2,5-bis[(4-fluorophenyl)iminomethyl]furan
by: Moira K. Lauer, et al.
Published: (2025-07-01)

Crystal structure and Hirshfeld-surface analysis of 1-(4-fluorophenyl)-3,3-bis(methylsulfanyl)prop-2-en-1-one
by: Thaluru M. Mohan Kumar, et al.
Published: (2025-06-01)

The crystal structure of (5-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-sulfanylidene-1,3,4-oxadiazol-3(2H)-yl)(3-methylphenyl)methanone, C18H14N2O4S
by: Jiang Zi-Hui, et al.
Published: (2025-08-01)

Syntheses and structures of 1-[2,2-dichloro-1-hydroxy-3-(4-methylphenyl)-3-oxopropyl]urea and 1-[2,2-dichloro-3-(4-fluorophenyl)-1-hydroxy-3-oxopropyl]urea
by: Firudin I. Guseinov, et al.
Published: (2025-06-01)

Synthesis, structural elucidation, and antimicrobial evaluation of (2E)-3-(4-fluorophenyl)-1-(4-isopropylphenyl)prop-2-en-1-one: insights from experimental and computational studies
by: Nutan V. Sadgir, et al.
Published: (2025-05-01)

Crystal structure of (3-(dimethoxymethyl)-5-methoxy-1H-indol-1-yl)(5-fluoro-2-iodophenyl)methanone, C19H17FINO4
by: Yuan Jia-Cheng, et al.
Published: (2024-12-01)

SYNTHESIS AND CATECHOLASE ACTIVITY OF Cu(II) AND Fe(III) COMPLEXES OF 4-METHYL-2-((PIPERIDIN-1-YL)METHYL)PHENOL
by: AYOWOLE O. AYENI, et al.
Published: (2020-12-01)

Novel Thiazole-Fused [4,5-<i>g</i>] or [5,4-<i>g</i>]Quinazolin-8-ones and Their Quinazoline Analogues: Synthesis and Biological Evaluation
by: Nathan Broudic, et al.
Published: (2024-10-01)

Synthesis, crystal structure and Hirshfeld surface analysis of 2,2-dichloro-3,3-diethoxy-1-(4-fluorophenyl)propan-1-ol
by: Saadet N. Guseynova, et al.
Published: (2025-05-01)

6-Amino-7-((4-methoxybenzyl)thio)quinazolin-4(3<i>H</i>)-one
by: Susila Thapa, et al.
Published: (2024-12-01)

Quantitative analysis of piperidin-1-ium {[5-(2-furyl)-4-phenyl-4h-1,2,4-triazol-3-yl]thio}acetate, substance of the veterinary drug “tryfuzol”, in poultry meat by lc–dad–ms
by: B. O. Varynskyi, et al.
Published: (2015-08-01)

Synthesis and structure of some new Schiff bases, derivatives of 2-((4-((R-benzylidene)amino)-5-(2-fluorophenyl)-4H-1,2,4-triazole-3-yl)thio)acetohydrazides
by: Ye. S. Pruglo
Published: (2018-08-01)