Automated Synthesis and Initial Evaluation of (4′-Amino-5′,8′-difluoro-1′H-spiro[piperidine-4,2′-quinazolin]-1-yl)(4-[18F]fluorophenyl)methanone for PET/MR Imaging of Inducible Nitric Oxide Synthase

Automated Synthesis and Initial Evaluation of (4′-Amino-5′,8′-difluoro-1′H-spiro[piperidine-4,2′-quinazolin]-1-yl)(4-[18F]fluorophenyl)methanone for PET/MR Imaging of Inducible Nitric Oxide Synthase

Background. Inducible nitric oxide synthase (iNOS) plays a crucial role in neuroinflammation, especially microglial activity, and may potentially represent a useful biomarker of neuroinflammation. In this study, we carefully defined a strategic plan to develop iNOS-targeted molecular PET imaging usi...

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Main Authors: Skye Hsin-Hsien Yeh, Wen-Sheng Huang, Chuang-Hsin Chiu, Chuan-Lin Chen, Hui-Ting Chen, Dae Yoon Chi, Zhengxing Ge, Tsung-Hsun Yu, Pao-Yeh Wang, Yu-Yeh Kuo, Chun-Tse Hung, Geng-Ying Li, Chi-Wei Chang
Format: Article
Language:English
Published: SAGE Publishing 2021-01-01
Series:Molecular Imaging
Online Access:http://dx.doi.org/10.1155/2021/9996125
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http://dx.doi.org/10.1155/2021/9996125

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