Development of an Immunodeficient Pig Model for Pancreatic Cancer Xenotransplantation Using Splenectomy, Thymectomy, and Oral Immunosuppression

Development of an Immunodeficient Pig Model for Pancreatic Cancer Xenotransplantation Using Splenectomy, Thymectomy, and Oral Immunosuppression

<i>Background and Objectives</i>: Animal models are widely used in medical research, but most are limited to small or medium-sized species due to logistical constraints. However, pancreatic cancer research and surgical xenograft models require large animals with anatomical similarities t...

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Bibliographic Details
Main Authors: Jun Suh Lee, Yoo-Seok Yoon, Ho-Seong Han, Jai Young Cho, Hae-Won Lee, Boram Lee, Yeshong Park, MeeYoung Kang
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Medicina
Subjects:
animal model
patient-derived xenograft
immunosuppression
pig model
Online Access:https://www.mdpi.com/1648-9144/61/4/586
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