Optical Spectroscopic Detection of Mitochondrial Biomarkers (FMN and NADH) for Hypothermic Oxygenated Machine Perfusion: A Comparative Study in Different Perfusion Media

Optical Spectroscopic Detection of Mitochondrial Biomarkers (FMN and NADH) for Hypothermic Oxygenated Machine Perfusion: A Comparative Study in Different Perfusion Media

Ex situ machine perfusion has emerged as a pivotal technique for organ preservation and pre-transplant viability assessment, where the real-time monitoring of mitochondrial biomarkers—flavin mononucleotide (FMN) and nicotinamide adenine dinucleotide (NADH)—could significantly mitigate ischemia-reper...

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Main Authors: Lorenzo Agostino Cadinu, Keyue Sun, Chunbao Jiao, Rebecca Panconesi, Sangeeta Satish, Fatma Selin Yildirim, Omer Faruk Karakaya, Chase J. Wehrle, Geofia Shaina Crasta, Fernanda Walsh Fernandes, Nasim Eshraghi, Koki Takase, Hiroshi Horie, Pier Carlo Ricci, Davide Bagnoli, Mauricio Flores Carvalho, Andrea Schlegel, Massimo Barbaro
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Sensors
Subjects:
mitochondrial molecular biomarkers
spectroscopy application
optic phenomena in perfusion solution
spectroscopic calibration
methodologies and protocols
optic sensor theoretical foundations
Online Access:https://www.mdpi.com/1424-8220/25/13/4031
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