M2 macrophage-derived mitochondrial transplantation promotes periodontal bone regeneration by regulating metabolic homeostasis via activating p38-MAPK signaling pathway

M2 macrophage-derived mitochondrial transplantation promotes periodontal bone regeneration by regulating metabolic homeostasis via activating p38-MAPK signaling pathway

Abstract Background Research indicates that the mitochondrial function of mesenchymal stem cells in the periodontal inflammatory microenvironment is impaired, leading to insufficient osteogenic differentiation. Mitochondrial transplantation has emerged as a promising treatment for mitochondrial dysf...

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Bibliographic Details
Main Authors: Yuzhuo Ma, Xiang Han, Ke Yan, Yiyang Yang, Kewei Zhang, Yue Wang, Xuerong Lv, Feiyang Wang, Xiaoqian Wang
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Stem Cell Research & Therapy
Subjects:
Mitochondrial transplantation
M2 macrophages
Inflammatory microenvironment
Periodontal ligament stem cells
Metabolic homeostasis
Osteogenic differentiation
Online Access:https://doi.org/10.1186/s13287-025-04444-w
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https://doi.org/10.1186/s13287-025-04444-w

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