Congenital Anomalies of the Kidney and Urinary Tract: A Genetic Disorder?
Congenital anomalies of the kidney and urinary tract (CAKUTs) occur in 3–6 per 1000 live births, account for the most cases of pediatric end-stage kidney disease (ESKD), and predispose an individual to hypertension and cardiovascular disease throughout life. Although CAKUTs are a part of many known...
Saved in:
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | International Journal of Nephrology |
| Online Access: | http://dx.doi.org/10.1155/2012/909083 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832558247905591296 |
|---|---|
| author | Ihor V. Yosypiv |
| author_facet | Ihor V. Yosypiv |
| author_sort | Ihor V. Yosypiv |
| collection | DOAJ |
| description | Congenital anomalies of the kidney and urinary tract (CAKUTs) occur in 3–6 per 1000 live births, account for the most cases of pediatric end-stage kidney disease (ESKD), and predispose an individual to hypertension and cardiovascular disease throughout life. Although CAKUTs are a part of many known syndromes, only few single-candidate causative genes have been implicated so far in nonsyndromic cases of human CAKUT. Evidence from mouse models supports the hypothesis that non-syndromic human CAKUT may be caused by single-gene defects. Because increasing numbers of children with CAKUT are surviving to adulthood, better understanding of the molecular pathogenesis of CAKUT, development of new strategies aiming at prevention of CAKUT, preservation of renal function, and avoidance of associated cardiovascular morbidity are needed. In this paper, we will focus on the knowledge derived from the study of syndromic and non-syndromic forms of CAKUT in humans and mouse mutants to discuss the role of genetic, epigenetic, and in utero environmental factors in the pathogenesis of non-syndromic forms of CAKUT in children with particular emphasis on the genetic contributions to CAKUT. |
| format | Article |
| id | doaj-art-70d73d92094c40ec89a189be9ea9295c |
| institution | Kabale University |
| issn | 2090-214X 2090-2158 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Nephrology |
| spelling | doaj-art-70d73d92094c40ec89a189be9ea9295c2025-02-03T01:32:50ZengWileyInternational Journal of Nephrology2090-214X2090-21582012-01-01201210.1155/2012/909083909083Congenital Anomalies of the Kidney and Urinary Tract: A Genetic Disorder?Ihor V. Yosypiv0Section of Pediatric Nephrology, Department of Pediatrics, Hypertension and Renal Center of Excellence, Tulane University Health Sciences Center, New Orleans, LA 70112, USACongenital anomalies of the kidney and urinary tract (CAKUTs) occur in 3–6 per 1000 live births, account for the most cases of pediatric end-stage kidney disease (ESKD), and predispose an individual to hypertension and cardiovascular disease throughout life. Although CAKUTs are a part of many known syndromes, only few single-candidate causative genes have been implicated so far in nonsyndromic cases of human CAKUT. Evidence from mouse models supports the hypothesis that non-syndromic human CAKUT may be caused by single-gene defects. Because increasing numbers of children with CAKUT are surviving to adulthood, better understanding of the molecular pathogenesis of CAKUT, development of new strategies aiming at prevention of CAKUT, preservation of renal function, and avoidance of associated cardiovascular morbidity are needed. In this paper, we will focus on the knowledge derived from the study of syndromic and non-syndromic forms of CAKUT in humans and mouse mutants to discuss the role of genetic, epigenetic, and in utero environmental factors in the pathogenesis of non-syndromic forms of CAKUT in children with particular emphasis on the genetic contributions to CAKUT.http://dx.doi.org/10.1155/2012/909083 |
| spellingShingle | Ihor V. Yosypiv Congenital Anomalies of the Kidney and Urinary Tract: A Genetic Disorder? International Journal of Nephrology |
| title | Congenital Anomalies of the Kidney and Urinary Tract: A Genetic Disorder? |
| title_full | Congenital Anomalies of the Kidney and Urinary Tract: A Genetic Disorder? |
| title_fullStr | Congenital Anomalies of the Kidney and Urinary Tract: A Genetic Disorder? |
| title_full_unstemmed | Congenital Anomalies of the Kidney and Urinary Tract: A Genetic Disorder? |
| title_short | Congenital Anomalies of the Kidney and Urinary Tract: A Genetic Disorder? |
| title_sort | congenital anomalies of the kidney and urinary tract a genetic disorder |
| url | http://dx.doi.org/10.1155/2012/909083 |
| work_keys_str_mv | AT ihorvyosypiv congenitalanomaliesofthekidneyandurinarytractageneticdisorder |