Cross modality learning of cell painting and transcriptomics data improves mechanism of action clustering and bioactivity modelling

Abstract In drug discovery, different data modalities (chemical structure, cell biology, quantum mechanics, etc.) are abundant, and their integration can help with understanding aspects of chemistry, biology, and their interactions. Within cell biology, cell painting (CP) and transcriptomics RNA-Seq...

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Bibliographic Details
Main Authors: Son V. Ha, Steffen Jaensch, Maciej M. Kańduła, Dorota Herman, Paul Czodrowski, Hugo Ceulemans
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-025-05914-0
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