Inhibition of endocannabinoid hydrolases MAGL, FAAH and ABHD6 by AKU-005 reduces ex vivo cortical spreading depression

Inhibition of endocannabinoid hydrolases MAGL, FAAH and ABHD6 by AKU-005 reduces ex vivo cortical spreading depression

Abstract Background Migraine is a common neurovascular disorder that remains currently untreated in half of the patients. One third of migraine patients experience aura, which is associated with the development of cortical spreading depolarization (CSD), a wave of depolarization involving neurons an...

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Main Authors: Flavia Brugia, Konstantin Ivanov, Auni Aroviita, Raisa Giniatullina, Marko Lehtonen, Tarja Malm, Juha Savinainen, Rashid Giniatullin, Adriana Della Pietra
Format: Article
Language:English
Published: BMC 2025-04-01
Series:The Journal of Headache and Pain
Subjects:
Headache
Endocannabinoids
Pain
Serine hydrolases
CSD
Online Access:https://doi.org/10.1186/s10194-025-02030-2
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https://doi.org/10.1186/s10194-025-02030-2

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