ARM-X: an adaptable mesenchymal stromal cell-based vaccination platform suitable for solid tumors

ARM-X: an adaptable mesenchymal stromal cell-based vaccination platform suitable for solid tumors

Abstract Background In addition to triggering endosomal escape, the Accum® platform was recently reported for its ability to instill antigen cross-presentation properties in mesenchymal stromal cells (MSCs). Despite the promising results obtained with the first-generation vaccine using the A1 Accum®...

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Main Authors: Jean Pierre Bikorimana, Nehme El-Hachem, Gabrielle A. Mandl, Daniela Stanga, Jamilah Abusarah, Roudy Farah, Marina P. Gonçalves, Perla Matar, Malak Lahrichi, Sebastien Talbot, Moutih Rafei
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Stem Cell Research & Therapy
Subjects:
Allogeneic cell vaccine
AccuTOX®
Mesenchymal stromal cells
Endosomal escape
Antigen cross-presentation
Reactive oxygen species
Online Access:https://doi.org/10.1186/s13287-025-04465-5
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https://doi.org/10.1186/s13287-025-04465-5

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