Prediction of human pharmacokinetics of Fc-engineered therapeutic monoclonal antibodies using human FcRn transgenic mice

Prediction of human pharmacokinetics of Fc-engineered therapeutic monoclonal antibodies using human FcRn transgenic mice

Human FcRn transgenic mice (Tg32) have been widely used to evaluate the pharmacokinetics of mAbs and predict human pharmacokinetics. This study aims to establish an approach for predicting the human pharmacokinetics of Fc-engineered mAbs with enhanced FcRn binding mutations using Tg32 mice. MAbs wer...

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Bibliographic Details
Main Authors: Kenta Haraya, Takuya Ichikawa, Naoaki Murao, Hitoshi Katada, Taichi Kuramochi
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:mAbs
Subjects:
Allometric scaling
Fc engineered mabs
FcRn
pharmacokinetics
Tg32
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2025.2484443
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https://www.tandfonline.com/doi/10.1080/19420862.2025.2484443

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