Galectin-9 treatment is cytotoxic for B cell lymphoma by disrupting autophagy

Galectin-9 treatment is cytotoxic for B cell lymphoma by disrupting autophagy

IntroductionThe main cause of death for patients with non-Hodgkin lymphoma (NHL) remains therapy resistant relapses. Chemoresistance is commonly associated with apoptosis defects and upregulated autophagy. Therefore, novel therapeutic options that do not rely on apoptosis and target autophagy would...

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Bibliographic Details
Main Authors: Lisanne Koll, Harm Jan Lourens, Glenn Marsman, Stan de Haan, Toshiro Niki, Gerwin A. Huls, Edwin Bremer, Valerie R. Wiersma
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Pharmacology
Subjects:
galectin-9 (Gal-9)
B cell lymphoma
cell death
autophagy
chemoresistance
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1601235/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1601235/full

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