Scale‐Up of Human Amniotic Epithelial Cells Through Regulation of Epithelial‐Mesenchymal Plasticity Under Defined Conditions

Scale‐Up of Human Amniotic Epithelial Cells Through Regulation of Epithelial‐Mesenchymal Plasticity Under Defined Conditions

Abstract Human amniotic epithelial cells (hAECs) have shown excellent efficacy in clinical research and have prospective applications in the treatment of many diseases. However, the properties of the hAECs and their proliferative mechanisms remain unclear. Here, single‐cell RNA sequencing (scRNA‐seq...

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Main Authors: Wangping Hao, Yi Luo, Jia Tian, Yuefeng Lu, Yangyang Cui, Ying Zhang, Xiao Jin, Hongjuan Ye, Mengqi Lu, Jinjia Song, Weiqing Zhou, Wencheng Zhang, Zhiying He
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:Advanced Science
Subjects:
3D microcarrier expansion
epithelial‐mesenchymal plasticity (EMP)
human amniotic epithelial cells (hAECs)
partial epithelial‐mesenchymal transition (pEMT)
single‐cell RNA sequencing (scRNA‐seq)
Online Access:https://doi.org/10.1002/advs.202408581
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https://doi.org/10.1002/advs.202408581

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