Activation of PI3K-AKT pathway prevents steroid-induced osteonecrosis of the femoral head via inhibiting Cuproptosis

Activation of PI3K-AKT pathway prevents steroid-induced osteonecrosis of the femoral head via inhibiting Cuproptosis

Abstract This study delved into the role of the PI3K/AKT signaling pathway and cuproptosis in steroid-induced osteonecrosis of the femoral head (SIONFH), assessing the therapeutic potential of the PI3K agonist 740Y-P. We analyzed femoral head specimens from SIONFH patients using DIA proteomics, iden...

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Bibliographic Details
Main Authors: Shihua Gao, Haoran Zhu, Hongxing Chen, Hongduo Lu, Moshan Wen, Yinuo Fan, Deqiang Yang, Hu Li
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Scientific Reports
Subjects:
Steroid-induced osteonecrosis of the femoral head
PI3K/AKT signaling pathway
740Y-P
Cuproptosis
Dexamethasone
Online Access:https://doi.org/10.1038/s41598-025-93555-8
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https://doi.org/10.1038/s41598-025-93555-8

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