PHOSPHO1 Suppresses Ferroptosis in Retinal Pigment Epithelial Cells by Reducing the Levels of Phosphatidylethanolamine Molecular Species

PHOSPHO1 Suppresses Ferroptosis in Retinal Pigment Epithelial Cells by Reducing the Levels of Phosphatidylethanolamine Molecular Species

Abstract Iron‐induced lipid peroxidation of phosphatidylethanolamine (PE) species is a key driver of ferroptosis in retinal pigment epithelial (RPE) cells, a process closely associated with age‐related macular degeneration (AMD). The previous studies have demonstrated that induced retinal pigment ep...

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Main Authors: Zhiyang Chen, Xiaoman Zhu, Michael Mingze Lu, Qingjian Ou, Xueying Wang, Zhenzhen Zhao, Qi Shen, Qian Wang, Zhe Wang, Jing‐Ying Xu, Caixia Jin, Furong Gao, Juan Wang, Jingfa Zhang, Jieping Zhang, Xiaoliang Jin, Yanlong Bi, Lixia Lu, Guo‐Tong Xu, Haibin Tian
Format: Article
Language:English
Published: Wiley 2025-07-01
Series:Advanced Science
Subjects:
age‐related macular degeneration
ferroptosis
phosphatidylethanolamine
phosphoethanolamine/phosphocholine phosphatase 1
retinal pigment epithelial cells
Online Access:https://doi.org/10.1002/advs.202505359
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https://doi.org/10.1002/advs.202505359

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