Intraspecies associations from strain-rich metagenome samples

Summary: Genetically distinct strains of a species can vary widely in phenotype, reducing the utility of species-resolved microbiome measurements for detecting associations with health or disease. While metagenomics theoretically provides information on all strains in a sample, current strain-resolv...

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Bibliographic Details
Main Authors: Evan B. Qu, Jacob S. Baker, Laura Markey, Veda Khadka, Chris Mancuso, A. Delphine Tripp, Tami D. Lieberman
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Cell Reports
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Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725009052
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