PKCβ phosphorylates PI3Kγ to activate it and release it from GPCR control.

PKCβ phosphorylates PI3Kγ to activate it and release it from GPCR control.

All class I phosphoinositide 3-kinases (PI3Ks) associate tightly with regulatory subunits through interactions that have been thought to be constitutive. PI3Kγ is key to the regulation of immune cell responses activated by G protein-coupled receptors (GPCRs). Remarkably we find that PKCβ phosphoryla...

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Main Authors: Romy Walser, John E Burke, Elena Gogvadze, Thomas Bohnacker, Xuxiao Zhang, Daniel Hess, Peter Küenzi, Michael Leitges, Emilio Hirsch, Roger L Williams, Muriel Laffargue, Matthias P Wymann
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.1001587
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https://doi.org/10.1371/journal.pbio.1001587

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