Genotype inference from aggregated chromatin accessibility data reveals genetic regulatory mechanisms

Abstract Background Understanding the genetic causes underlying variability in chromatin accessibility can shed light on the molecular mechanisms through which genetic variants may affect complex traits. Thousands of ATAC-seq samples have been collected that hold information about chromatin accessib...

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Bibliographic Details
Main Authors: Brandon M. Wenz, Yuan He, Nae-Chyun Chen, Joseph K. Pickrell, Jeremiah H. Li, Max F. Dudek, Taibo Li, Rebecca Keener, Benjamin F. Voight, Christopher D. Brown, Alexis Battle
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Genome Biology
Online Access:https://doi.org/10.1186/s13059-025-03538-1
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