Rac1 Temporarily Suppresses Fertilization Envelope Formation Immediately After 1-Methyladenine Stimulation

Rac1 Temporarily Suppresses Fertilization Envelope Formation Immediately After 1-Methyladenine Stimulation

In starfish oocytes, the hormone 1-methyladenine (1-MA) induces germinal vesicle breakdown (GVBD) through a signaling cascade involving PI3K, SGK, Cdc25, and Cdk1/cyclin via G-proteinβγ subunit. Following GVBD, fertilization triggers an intracellular calcium increase, leading to the formation of the...

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Bibliographic Details
Main Authors: Sakurako Aida, Takako Matsumoto, Yuna Yamazaki, Nunzia Limatola, Luigia Santella, Kazuyoshi Chiba
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Cells
Subjects:
starfish
oocyte maturation
Rac1
actin
calcium
fertilization
Online Access:https://www.mdpi.com/2073-4409/14/6/405
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