High-throughput method characterizes hundreds of previously unknown antibiotic resistance mutations

Abstract A fundamental obstacle to tackling the antimicrobial resistance crisis is identifying mutations that lead to resistance in a given genomic background and environment. We present a high-throughput technique – Quantitative Mutational Scan sequencing (QMS-seq) – that enables quantitative compa...

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Bibliographic Details
Main Authors: Matthew J. Jago, Jake K. Soley, Stepan Denisov, Calum J. Walsh, Danna R. Gifford, Benjamin P. Howden, Mato Lagator
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-56050-2
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