Modeling the impact of intercellular signaling on dose metrics and therapeutic outcomes in spatially fractionated radiation therapy (SFRT) for lung cancer
Abstract Spatially fractionated radiation therapy (SFRT) delivers heterogeneous dose distributions to enhance tumor control while reducing normal tissue toxicity. Since conventional models like the linear-quadratic (LQ) model overlook intercellular signaling, a key factor in non-uniform fields, this...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-08-01
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| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-025-11937-4 |
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