Modeling the impact of intercellular signaling on dose metrics and therapeutic outcomes in spatially fractionated radiation therapy (SFRT) for lung cancer

Modeling the impact of intercellular signaling on dose metrics and therapeutic outcomes in spatially fractionated radiation therapy (SFRT) for lung cancer

Abstract Spatially fractionated radiation therapy (SFRT) delivers heterogeneous dose distributions to enhance tumor control while reducing normal tissue toxicity. Since conventional models like the linear-quadratic (LQ) model overlook intercellular signaling, a key factor in non-uniform fields, this...

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Bibliographic Details
Main Authors: Elnaz Balvasi, Farshid Mahmoudi, Ghazale Geraily, Parastoo Farnia, Fatemeh Jafari
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Spatially fractionated radiotherapy
GRID therapy
Volumetric-modulated arc therapy
Bystander effect
Intercellular signaling
Online Access:https://doi.org/10.1038/s41598-025-11937-4
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https://doi.org/10.1038/s41598-025-11937-4

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