The Molecular Basis of the Intrinsic and Acquired Resistance to Azole Antifungals in <i>Aspergillus fumigatus</i>

The Molecular Basis of the Intrinsic and Acquired Resistance to Azole Antifungals in <i>Aspergillus fumigatus</i>

<i>Aspergillus fumigatus</i> is intrinsically resistant to the widely used antifungal fluconazole, and therapeutic failure can result from acquired resistance to voriconazole, the primary treatment for invasive aspergillosis. The molecular basis of substrate specificity and innate and ac...

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Bibliographic Details
Main Authors: Parham Hosseini, Mikhail V. Keniya, Alia A. Sagatova, Stephanie Toepfer, Christoph Müller, Joel D. A. Tyndall, Anette Klinger, Edmond Fleischer, Brian C. Monk
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Journal of Fungi
Subjects:
<i>Aspergillus fumigatus</i> CYP51
ERG6
CPRA
eburicol
fluconazole
voriconazole
Online Access:https://www.mdpi.com/2309-608X/10/12/820
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