Celastrol, an NF-κB inhibitor, improves insulin resistance and attenuates renal injury in db/db mice.

Celastrol, an NF-κB inhibitor, improves insulin resistance and attenuates renal injury in db/db mice.

The NF-κB pathway plays an important role in chronic inflammatory and autoimmune diseases. Recently, NF-κB has also been suggested as an important mechanism linking obesity, inflammation, and metabolic disorders. However, there is no current evidence regarding the mechanism of action of NF-κB inhibi...

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Main Authors: Jung Eun Kim, Mi Hwa Lee, Deok Hwa Nam, Hye Kyoung Song, Young Sun Kang, Ji Eun Lee, Hyun Wook Kim, Jin Joo Cha, Young Youl Hyun, Sang Youb Han, Kum Hyun Han, Jee Young Han, Dae Ryong Cha
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0062068&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0062068&type=printable

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