Asb10 accelerates pathological cardiac remodeling by stabilizing HSP70

Abstract Cardiac hypertrophy is a pivotal risk factor for heart failure. Hypertension-induced pressure overload triggers left ventricular hypertrophy and leads to heart failure. Although the precise mechanisms remain incompletely elucidated, recent studies highlighted the role of ubiquitin-proteasom...

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Main Authors: Ke Lin, Wenjie Wei, Songzan Chen, Yingchao Gong, Xingchen Wang, Meihui Wang, Ran Li, Yanbo Zhao, Shengjie Xu, Chongying Jin, Chenyang Jiang, Guosheng Fu, Qinfeng Li
Format: Article
Language:English
Published: Nature Publishing Group 2025-05-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-025-07735-5
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