Prediction of SPT-07A Pharmacokinetics in Rats, Dogs, and Humans Using a Physiologically-Based Pharmacokinetic Model and In Vitro Data

Prediction of SPT-07A Pharmacokinetics in Rats, Dogs, and Humans Using a Physiologically-Based Pharmacokinetic Model and In Vitro Data

<b>Background/Objectives:</b> SPT-07A, a D-borneol, is currently being developed in China for the treatment of ischemic stroke. We aimed to create a whole-body physiologically-based pharmacokinetic (PBPK) model to predict the pharmacokinetics of SPT-07A in rats, dogs, and humans. <b&g...

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Bibliographic Details
Main Authors: Xiaoqiang Zhu, Weimin Kong, Zehua Wang, Xiaodong Liu, Li Liu
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Pharmaceutics
Subjects:
SPT-07A
ischemic stroke
physiologically-based pharmacokinetic model
interspecies allometric scaling
unbound fraction in plasma
UDP-glucuronosyltransferases
Online Access:https://www.mdpi.com/1999-4923/16/12/1596
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