3,3′-Diindolylmethane improves pathology and neurological outcome following traumatic brain injury

3,3′-Diindolylmethane improves pathology and neurological outcome following traumatic brain injury

3,3′-Diindolylmethane (DIM), a naturally occurring bis-indole found in cruciferous vegetables and produced in small amounts in the normal flora of the human gut, has demonstrated neuroprotective benefits in models of CNS hypoxia and stroke. In the CNS, DIM modulates the activation of the aryl hydroc...

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Bibliographic Details
Main Authors: Carlos A. Dallera, Fabiola Placeres-Uray, Patrizzia Mastromatteo-Alberga, Maria Dominguez-Torres, Alyssa F. Balleste, Aditi S. Gorthy, Tyler S. Rahimzadeh, Isabelle Aliancin, W. Dalton Dietrich, Juan Pablo de Rivero Vaccari, Irwin C. Jacobs, Elizabeth A. Chlipala, Hannah Benton, Michael A. Zeligs, Coleen M. Atkins
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Neurotherapeutics
Subjects:
Blood-brain barrier
Diindolylmethane
Edema
Extracellular vesicles
Learning and memory
Traumatic brain injury
Online Access:http://www.sciencedirect.com/science/article/pii/S1878747925000091
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