Use of epigenetically modified bacteriophage and dual beta-lactams to treat a Mycobacterium abscessus sternal wound infection

Use of epigenetically modified bacteriophage and dual beta-lactams to treat a Mycobacterium abscessus sternal wound infection

Abstract Nontuberculous mycobacterium (NTM) infections are challenging to manage and are frequently non-responsive to aggressive but poorly-tolerated antibiotic therapies. Immunosuppressed lung transplant patients are susceptible to NTM infections and poor patient outcomes are common. Bacteriophages...

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Main Authors: Madison Cristinziano, Elena Shashkina, Liang Chen, Jaime Xiao, Melissa B. Miller, Christina Doligalski, Raymond Coakley, Leonard Jason Lobo, Brent Footer, Luther Bartelt, Lawrence Abad, Daniel A. Russell, Rebecca Garlena, Michael J. Lauer, Maggie Viland, Ari Kaganovsky, Emily Mowry, Deborah Jacobs-Sera, David van Duin, Barry N. Kreiswirth, Graham F. Hatfull, Anne Friedland
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-54666-4
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https://doi.org/10.1038/s41467-024-54666-4

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