KAT5 regulates neurodevelopmental states associated with G0-like populations in glioblastoma

KAT5 regulates neurodevelopmental states associated with G0-like populations in glioblastoma

Abstract Quiescence cancer stem-like cells may play key roles in promoting tumor cell heterogeneity and recurrence for many tumors, including glioblastoma (GBM). Here we show that the protein acetyltransferase KAT5 is a key regulator of transcriptional, epigenetic, and proliferative heterogeneity im...

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Main Authors: Anca B. Mihalas, Sonali Arora, Samantha A. O’Connor, Heather M. Feldman, Christine E. Cucinotta, Kelly Mitchell, John Bassett, Dayoung Kim, Kang Jin, Pia Hoellerbauer, Jennifer Delegard, Melissa Ling, Wesley Jenkins, Megan Kufeld, Philip Corrin, Lucas Carter, Toshio Tsukiyama, Bruce Aronow, Christopher L. Plaisier, Anoop P. Patel, Patrick J. Paddison
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-59503-w
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https://doi.org/10.1038/s41467-025-59503-w

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