Efficacy and Safety of Intravenous Tenecteplase Before Endovascular Thrombectomy for Acute Ischemic Stroke: The Multicenter, Randomized, BRIDGE‐TNK Trial Protocol

Efficacy and Safety of Intravenous Tenecteplase Before Endovascular Thrombectomy for Acute Ischemic Stroke: The Multicenter, Randomized, BRIDGE‐TNK Trial Protocol

Background Six randomized trials have not detected a difference between intravenous alteplase plus endovascular thrombectomy and endovascular thrombectomy alone in stroke. Tenecteplase, a recombinant human tenecteplase tissue‐type plasminogen activator, is a genetically modified variant of alteplase...

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Main Authors: Zhongming Qiu, Fengli Li, Dongjing Xie, Guangxiong Yuan, Thanh N. Nguyen, Kai Zhou, Raul G. Nogueira, Jeffrey L. Saver, Bruce C.V. Campbell, Gregory W. Albers, Hongfei Sang, Linyu Li, Yan Tian, Zhaoyou Meng, Duolao Wang, Wenjie Zi, Qingwu Yang
Format: Article
Language:English
Published: Wiley 2024-11-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
acute ischemic stroke
endovascular treatment
large‐vessel occlusion
protocol
randomized trial
tenecteplase
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.124.036765
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https://www.ahajournals.org/doi/10.1161/JAHA.124.036765

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