Legionella pneumophila type II secretome reveals a polysaccharide deacetylase that impacts intracellular infection, biofilm formation, and resistance to polymyxin- and serum-mediated killing

Legionella pneumophila type II secretome reveals a polysaccharide deacetylase that impacts intracellular infection, biofilm formation, and resistance to polymyxin- and serum-mediated killing

ABSTRACT Prior analyses suggested that the type II secretion system (T2SS) of Legionella pneumophila secretes ≥47 proteins beyond its 26 known substrates. Upon examination of mutants of wild-type strain 130b that lack those exoproteins most conserved across the Legionella genus, we discovered that p...

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Bibliographic Details
Main Authors: Carlton O. Adams, Jackson A. Campbell, Beichang Zhang, Leanne Cleaver, Sarah B. Bier, Joshua Mayoral, Richard C. White, James A. Garnett, Nicholas P. Cianciotto
Format: Article
Language:English
Published: American Society for Microbiology 2025-07-01
Series:mBio
Subjects:
L. pneumophila
T2SS
polysaccharide deacetylase
PdaA
lipopolysaccharide
intracellular infection
Online Access:https://journals.asm.org/doi/10.1128/mbio.01393-25
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https://journals.asm.org/doi/10.1128/mbio.01393-25

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