Cocrystal pleomorphism-inspired drug nanoassembly for pulmonary-endothelium targeting and pulmonary hypertension treatment

Cocrystal pleomorphism-inspired drug nanoassembly for pulmonary-endothelium targeting and pulmonary hypertension treatment

Endothelial dysfunction is one of the early triggers of vascular remodeling during pulmonary hypertension (PH) with complex predisposing mechanisms, mainly via an unbalanced generation of vasoactive factors, increased expression of growth factors, prothrombotic elements, and inflammatory markers. Co...

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Bibliographic Details
Main Authors: Makhloufi Zoulikha, Jiahui Zou, Pei Yang, Jun Wu, Wei Wu, Kun Hao, Wei He
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Pulmonary hypertension
Inflammation
Endothelial dysfunction
Endothelin
Cocrystals
Nanorods
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383524004416
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http://www.sciencedirect.com/science/article/pii/S2211383524004416

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