Mechanisms of asiaticoside in keloid treatment: Insights from a single-cell transcriptomic approach combined with network pharmacological analysis

Mechanisms of asiaticoside in keloid treatment: Insights from a single-cell transcriptomic approach combined with network pharmacological analysis

This work sought to clarify the molecular processes through which asiaticoside operates in treating keloid by utilizing an integrated approach employing scRNA-seq and systems pharmacological methods. We performed scRNA-seq on three patients' keloid and adjacent normal skin samples. We detected...

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Bibliographic Details
Main Authors: Xiaobo Zhou, Li Lin, Canbin Dong, Jui-Ming Lin, Yiyi Gong, Wenyu Wu, Jia Huang
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Alexandria Engineering Journal
Subjects:
Asiaticoside
Keloid
Single-cell RNA sequencing
Network pharmacology
Macrophages
Keloid fibroblast
Online Access:http://www.sciencedirect.com/science/article/pii/S1110016825005824
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