Critical amino acid residues in human ACE2 for SARS-CoV-2 spike protein binding and virus entry

Critical amino acid residues in human ACE2 for SARS-CoV-2 spike protein binding and virus entry

ABSTRACT The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), remains a significant global public health concern due to the continuous emergence and rapid spread of new variants. SARS-CoV-2 utilizes angiotensin-converting enzyme 2...

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Bibliographic Details
Main Authors: Weiyi Chen, Joo-Youn Lee, Jae-Sung Kim, Jin Soo Shin, To Sing Fung, Jung-Yong Yeh, Zhenhai Chen, Bin Zhou, Ji-Joon Song, Yun Young Go
Format: Article
Language:English
Published: American Society for Microbiology 2025-08-01
Series:Microbiology Spectrum
Subjects:
SARS-CoV-2
S-ACE2 interaction
ACE2 variants
amino acid substitutions
virus entry
binding affinity
Online Access:https://journals.asm.org/doi/10.1128/spectrum.03244-24
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https://journals.asm.org/doi/10.1128/spectrum.03244-24

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