Using transcripts to refine image based cell segmentation with FastReseg

Abstract Spatial transcriptomics (ST) faces persistent challenges in cell segmentation accuracy, which can bias biological interpretations in a spatial-dependent way. FastReseg introduces a novel algorithm that refines inaccuracies in existing image-based segmentations using transcriptomic data, wit...

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Bibliographic Details
Main Authors: Lidan Wu, Joseph M. Beechem, Patrick Danaher
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-025-08733-5
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