Direct detection of 8-oxo-dG using nanopore sequencing

Direct detection of 8-oxo-dG using nanopore sequencing

Abstract Genomic DNA is under constant oxidative damage, with 8-oxo-7,8-dihydro-2’-deoxyguanosine (8-oxo-dG) being the prominent lesion linked to mutagenesis, epigenetics, and gene regulation. Existing methods to detect 8-oxo-dG rely on indirect approaches, while nanopore sequencing enables direct d...

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Main Authors: Marc Pagès-Gallego, Daan M. K. van Soest, Nicolle J. M. Besselink, Roy Straver, Janneke P. Keijer, Carlo Vermeulen, Alessio Marcozzi, Markus J. van Roosmalen, Ruben van Boxtel, Boudewijn M. T. Burgering, Tobias B. Dansen, Jeroen de Ridder
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60391-3
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https://doi.org/10.1038/s41467-025-60391-3

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