ANKK1, ANKRD50, GRK5, PACSIN1 and VPS8 are novel candidate genes associated with late onset Parkinson's disease: Definition of a novel predictive protocol based on polygenic model of inheritance

ANKK1, ANKRD50, GRK5, PACSIN1 and VPS8 are novel candidate genes associated with late onset Parkinson's disease: Definition of a novel predictive protocol based on polygenic model of inheritance

Parkinson's disease (PD) represents one of the most frequent neurodegenerative disorders for which genetic diagnosis is still challenging due to the high genetic heterogeneity associated with the disease and to the difficulty in interpreting test results. We have recently reported the identific...

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Main Authors: Federica Carrillo, Nicole Piera Palomba, Sara Pietracupa, Laura Ianiro, Giorgio Fortunato, Margherita Degasperi, Tiziana Giloni, Maria Ilenia De Bartolo, Luigi Pavone, Teresa Nutile, Nicola Modugno, Danilo Licastro, Teresa Esposito
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Neurobiology of Disease
Subjects:
Late onset Parkinson's disease
Whole exome sequencing
Novel candidate genes for Parkinson's disease
Rare variant burden analysis
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996125002128
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