Harnessing Hazara Virus as a Surrogate for Crimean–Congo Hemorrhagic Fever Virus Enables Inactivation Studies at a Low Biosafety Level

Harnessing Hazara Virus as a Surrogate for Crimean–Congo Hemorrhagic Fever Virus Enables Inactivation Studies at a Low Biosafety Level

Research on highly pathogenic biosafety level 4 (BSL-4) viruses that are classified as Select Agents involves transferring inactivated materials to lower containment levels for further analysis. Compliance with Select Agent and BSL-4 safety regulations necessitates the validation and verification of...

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Bibliographic Details
Main Authors: Judith Olejnik, Kristina Meier, Jarod N. Herrera, Daniel J. DeStasio, Dylan J. Deeney, Elizabeth Y. Flores, Mitchell R. White, Adam J. Hume, Elke Mühlberger
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Pathogens
Subjects:
virus inactivation
TRIzol
aldehydes
Hazara virus
Crimean-Congo hemorrhagic fever virus
negative sense RNA viruses
Online Access:https://www.mdpi.com/2076-0817/14/7/700
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