Design and in silico analysis of a novel peptide-based multiepitope vaccine against glioblastoma multiforme by targeting tumor-associated macrophage

Design and in silico analysis of a novel peptide-based multiepitope vaccine against glioblastoma multiforme by targeting tumor-associated macrophage

CD204 is a distinct indicator for tumor-associated macrophages (TAMs) in glioma. Evidence indicates that CD204-positive TAMs are involved in the aggressive behavior of various types of cancers. This study was conducted to develop a new and effective peptide-based vaccine for GBM, specifically target...

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Bibliographic Details
Main Authors: Reza Salahlou, Safar Farajnia, Effat Alizadeh, Siavoush Dastmalchi, Nasrin Bargahi, Leila Rahbarnia, Safooreh Hoseinpour Steyar
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Heliyon
Subjects:
Glioblastoma cancer
Tumor-associated macrophages
CD204
Immunotherapy
Molecular docking
Molecular dynamics (MD) simulation
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024168053
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