Low levels of tumor suppressor miR-3619 in plasma contribute to malignant outcomes and a target for nucleic acid therapy in esophageal cancer

Low levels of tumor suppressor miR-3619 in plasma contribute to malignant outcomes and a target for nucleic acid therapy in esophageal cancer

Abstract Recent studies indicate that reduced levels of certain tumor-suppressing microRNAs (miRNAs) circulating in the blood are linked to tumor progression and poor prognosis across various types of malignancies. Identified from a comprehensive analysis of the NCBI and miRNA databases, we tested t...

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Main Authors: Hiroshi Arakawa, Shuhei Komatsu, Takuma Kishimoto, Hajime Kamiya, Ryo Ishida, Yusuke Takashima, Keiji Nishibeppu, Jun Kiuchi, Taisuke Imamura, Takuma Ohashi, Hiroki Shimizu, Tomohiro Arita, Hirotaka Konishi, Atsushi Shiozaki, Takeshi Kubota, Hitoshi Fujiwara, Eigo Otsuji
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Biomarker
Nucleic acid therapy
Esophageal cancer
Plasma MicroRNA
In vivo model of nucleic acid therapy
Online Access:https://doi.org/10.1038/s41598-025-12246-6
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https://doi.org/10.1038/s41598-025-12246-6

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