Phosphatidylcholine-specific B cells are enriched among atypical CD11chigh and CD21low memory B cells in antiphospholipid syndrome

Phosphatidylcholine-specific B cells are enriched among atypical CD11chigh and CD21low memory B cells in antiphospholipid syndrome

BackgroundPatients with antiphospholipid syndrome (APS) carry an increased risk of thrombosis and adverse pregnancy outcomes due to the presence of antiphospholipid autoantibodies (aPL). However, the pathogenesis of the disease remains incompletely understood regarding various aPL and the role of au...

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Main Authors: Eduard Nitschke, Van Duc Dang, Hector Rincon-Arevalo, Franziska Szelinski, Jacob Ritter, Eva Schrezenmeier, Tobias Alexander, Tuan Anh Le, Yidan Chen, Annika Wiedemann, Jose-Bernardino Gonzalez, Andreia C. Lino, Ana-Luisa Stefanski, Thomas Dörner
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Immunology
Subjects:
B cells
adaptive immunity
antigen-specific B cells
APS - antiphospholipid syndrome
anti-phospholipid antibodies
secondary APS
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1585953/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1585953/full

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