PINK1 deficiency rewires early immune responses in a mouse model of Parkinson’s disease triggered by intestinal infection

PINK1 deficiency rewires early immune responses in a mouse model of Parkinson’s disease triggered by intestinal infection

Abstract Parkinson’s disease is characterized by a period of non-motor symptoms, including gastrointestinal dysfunction, preceding motor deficits by several years to decades. This long prodrome is suggestive of peripheral immunity involvement in the initiation of disease. We previously developed a m...

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Main Authors: Sherilyn Junelle Recinto, Alexandra Kazanova, Lin Liu, Brendan Cordeiro, Shobina Premachandran, Hicham Bessaiah, Alexis Allot, Elia Afanasiev, Sriparna Mukherjee, Jessica Pei, Adam MacDonald, Moein Yaqubi, Heidi M. McBride, Diana Matheoud, Louis-Eric Trudeau, Samantha Gruenheid, Jo Anne Stratton
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:npj Parkinson's Disease
Online Access:https://doi.org/10.1038/s41531-025-00945-w
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https://doi.org/10.1038/s41531-025-00945-w

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