Glioblastoma multiforme: an updated overview of temozolomide resistance mechanisms and strategies to overcome resistance

Glioblastoma multiforme: an updated overview of temozolomide resistance mechanisms and strategies to overcome resistance

Abstract Glioblastoma (GBM) is an aggressive primary brain tumor with high lethality. The typical treatment regimen includes post-surgical radiotherapy and temozolomide (TMZ) chemotherapy, which helps extend survival. Nevertheless, TMZ resistance occurs in approximately 50% of patients. This resista...

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Bibliographic Details
Main Authors: Jianlin Pu, Kai Yuan, Jian Tao, Yuliang Qin, Yongxin Li, Jing Fu, Zhong Li, Haimei Zhou, Zhengxiu Tang, Li Li, Xuesong Gai, Dongdong Qin
Format: Article
Language:English
Published: Springer 2025-05-01
Series:Discover Oncology
Subjects:
Glioblastoma
Temozolomide
Resistance
Combination therapy
Traditional Chinese medicine
Online Access:https://doi.org/10.1007/s12672-025-02567-3
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https://doi.org/10.1007/s12672-025-02567-3

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