SRT2104 enhances dendritic outgrowth and spine formation through Sirtuin 1-mediated mTORC1 signaling

SRT2104 enhances dendritic outgrowth and spine formation through Sirtuin 1-mediated mTORC1 signaling

Abstract Impaired neuroplasticity is a one of the key pathological mechanism of depression. Sirtuin 1 plays a crucial role in neuroplasticity; however, its precise mechanisms remain unclear. This study examined whether sirtuin 1 regulates dendritic outgrowth and spine formation via mTORC1 signaling...

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Bibliographic Details
Main Authors: Mi Kyoung Seo, Jung Goo Lee, Ji Hyun Kim, Dae-Hyun Seog, Sehoon Jeong, Seong-Ho Kim, Jin Young Lee, Sung Woo Park
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Depression
Dexamethasone
mTORC1 signaling
Neuroplasticity
Sirtuin 1
SRT2104
Online Access:https://doi.org/10.1038/s41598-025-06203-6
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https://doi.org/10.1038/s41598-025-06203-6

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