Lineage-specific CDK activity dynamics characterize early mammalian development

Lineage-specific CDK activity dynamics characterize early mammalian development

Summary: Cyclin-dependent kinases (CDKs) regulate proliferation dynamics and cell fate in response to extracellular inputs. It remains largely unknown how CDK activity fluctuates and influences cell commitment during early mammalian development. Here, we generated a mouse model expressing a CDK tran...

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Main Authors: Bechara Saykali, Andy D. Tran, James A. Cornwell, Matthew A. Caldwell, Paniz Rezvan Sangsari, Nicole Y. Morgan, Michael J. Kruhlak, Steven D. Cappell, Sergio Ruiz
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:Cell Reports
Subjects:
CP: Developmental biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725003298
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