Penicilazaphilone C triggers ferroptosis in triple-negative breast cancer cells via the MDM2/p53/SLC7 A11/GPX4 pathway

Penicilazaphilone C triggers ferroptosis in triple-negative breast cancer cells via the MDM2/p53/SLC7 A11/GPX4 pathway

Abstract Penicilazaphilone C (PAC) is a novel azaphilone isolated by our research team. While known for its antitumor properties, the potential of PAC to trigger ferroptosis in triple-negative breast cancer (TNBC) cells remains unexplored. This study aims to assess the ferroptotic induction capabili...

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Bibliographic Details
Main Authors: Hua-Tao Liang, Feng-Ying Huang, Wei-Jing Xie, Ming-Hui Chen, Ri-Hong Wu, Shu-Zhen Dai, Wen-Tian Xu, Wu-Ping Zheng, Guang-Hong Tan
Format: Article
Language:English
Published: Springer 2025-06-01
Series:Discover Oncology
Subjects:
Triple-negative breast cancer
Penicilazaphilone C
Ferroptosis
E3 ubiquitin ligase MDM2
Azaphilone compound
Online Access:https://doi.org/10.1007/s12672-025-02687-w
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https://doi.org/10.1007/s12672-025-02687-w

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