LncRNA NEAT1 sponges miR-214-3p to promote osteoblast differentiation through regulating the PI3K/AKT/mTOR pathway in aortic valve calcification

LncRNA NEAT1 sponges miR-214-3p to promote osteoblast differentiation through regulating the PI3K/AKT/mTOR pathway in aortic valve calcification

Abstract Calcific aortic valve disease (CAVD) is the common valvular disease associated with significant morbidity and mortality. Dysregulation of long non-coding RNA (lncRNA) has been implicated in the pathogenesis of CAVD. This study aims to investigate the role of NEAT1 in CAVD pathogenesis. NEAT...

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Bibliographic Details
Main Authors: Rongjian Xu, Yuhui Sun, Fangfei Tian, Min Zhao
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
LncRNA NEAT1
miR-214-3p
PTEN
Calcific aortic valve disease
The PI3K/AKT/mTOR pathway
Osteoblast differentiation
Online Access:https://doi.org/10.1038/s41598-025-98578-9
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https://doi.org/10.1038/s41598-025-98578-9

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