RIG‐I antiviral signaling drives interleukin‐23 production and psoriasis‐like skin disease

RIG‐I antiviral signaling drives interleukin‐23 production and psoriasis‐like skin disease

Abstract Retinoic acid inducible‐gene I (RIG‐I) functions as one of the major sensors of RNA viruses. DDX58, which encodes the RIG‐I protein, has been newly identified as a susceptibility gene in psoriasis. Here, we show that the activation of RIG‐I by 5′ppp‐dsRNA, its synthetic ligand, directly cau...

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Main Authors: Huiyuan Zhu, Fangzhou Lou, Qianqian Yin, Yuanyuan Gao, Yang Sun, Jing Bai, Zhenyao Xu, Zhaoyuan Liu, Wei Cai, Fang Ke, Lingyun Zhang, Hong Zhou, Hong Wang, Gang Wang, Xiang Chen, Hongxin Zhang, Zhugang Wang, Florent Ginhoux, Chuanjian Lu, Bing Su, Honglin Wang
Format: Article
Language:English
Published: Springer Nature 2017-04-01
Series:EMBO Molecular Medicine
Subjects:
DCs
interleukin‐23
NF‐κB
psoriasis
RIG‐I
Online Access:https://doi.org/10.15252/emmm.201607027
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https://doi.org/10.15252/emmm.201607027

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