Transplantation of miR-216a-5p-overexpressing mesenchymal stem cells encapsulated in a thermosensitive hydrogel promotes functional recovery in a rat model of spinal cord injury

Transplantation of miR-216a-5p-overexpressing mesenchymal stem cells encapsulated in a thermosensitive hydrogel promotes functional recovery in a rat model of spinal cord injury

Abstract To evaluate the therapeutic efficacy of mesenchymal stem cells (MSCs) overexpressing miR-216a-5p delivered via a thermosensitive hydrogel in a rat model of spinal cord injury (SCI). A thermosensitive hydrogel was engineered to encapsulate MSCs overexpressing miR-216a-5p (MSC-miR-216a-5p). T...

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Bibliographic Details
Main Authors: Zhi Dou, Liangliang He, Jianning Yue, Wenxing Zhao, Hongyan Wang, Jie Lu, Chao Wang, Liqiang Yang
Format: Article
Language:English
Published: BMC 2025-07-01
Series:European Journal of Medical Research
Subjects:
Spinal cord injury
Mesenchymal stem cells
Thermosensitive hydrogel
MiR-216a-5p
Online Access:https://doi.org/10.1186/s40001-025-02860-5
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https://doi.org/10.1186/s40001-025-02860-5

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