Role of eIF4E in mediating cytotoxic effect of HHT and ATO on AML cells in bone marrow microenvironment

Role of eIF4E in mediating cytotoxic effect of HHT and ATO on AML cells in bone marrow microenvironment

Background: The bone marrow (BM) microenvironment in acute myeloid leukemia (AML) shields leukemic cells from chemotherapy, fostering disease recurrence and progression.Objectives: This study investigated the impact of eukaryotic initiation factor 4E (eIF4E) in AML progression and chemosensitivity,...

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Bibliographic Details
Main Authors: Ping Chen, Xiaojing Li, Weiwu Zhan, Kaiting Lin, Bicun Lin, Xiaobin Lin, Meijuan Huang
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Hematology
Subjects:
EIF4E
acute myeloid leukemia
bone marrow stromal cell
homoharringtonine
arsenic trioxide
Online Access:https://www.tandfonline.com/doi/10.1080/16078454.2025.2546734
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https://www.tandfonline.com/doi/10.1080/16078454.2025.2546734

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