Tumor-associated macrophages promote intratumoral conversion of conventional CD4+ T cells into regulatory T cells via PD-1 signalling

Tumor-associated macrophages promote intratumoral conversion of conventional CD4+ T cells into regulatory T cells via PD-1 signalling

While regulatory T cells (Tregs) and macrophages have been recognized as key orchestrators of cancer-associated immunosuppression, their cellular crosstalk within tumors has been poorly characterized. Here, using spontaneous models for breast cancer, we demonstrate that tumor-associated macrophages...

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Bibliographic Details
Main Authors: Kevin Kos, Camilla Salvagno, Max D. Wellenstein, Muhammad A. Aslam, Denize A. Meijer, Cheei-Sing Hau, Kim Vrijland, Daphne Kaldenbach, Elisabeth A.M. Raeven, Martina Schmittnaegel, Carola H. Ries, Karin E. de Visser
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:OncoImmunology
Subjects:
Breast cancer immunology
regulatory T cells
tumor-associated macrophages
T cell plasticity
Online Access:https://www.tandfonline.com/doi/10.1080/2162402X.2022.2063225
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https://www.tandfonline.com/doi/10.1080/2162402X.2022.2063225

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